EigoPro 準1級 読解 — The Rise of Superbugs

When penicillin entered widespread use in the 1940s, it seemed to herald a future in which bacterial infection would be little more than a nuisance. For a generation, that promise largely held: diseases that had once killed routinely became treatable in days. Yet the very triumph of antibiotics sowed the seeds of their decline. Every time a drug is deployed, the bacteria it fails to kill survive and multiply, and over decades of relentless use—much of it unnecessary—the microbial world has been steadily reshaped in favour of resistance. The so-called superbugs that now circulate in hospitals are not an aberration but the predictable product of evolution operating at breathtaking speed. The drivers of this crisis are as much economic and social as biological. Antibiotics are cheap, briefly prescribed, and quickly cured patients move on; for a pharmaceutical company, a drug taken for ten days is far less lucrative than one taken for a lifetime. As a result, the pipeline of genuinely new antibiotics has nearly run dry, even as resistance spreads. Meanwhile, in agriculture, vast quantities of antibiotics are fed to healthy livestock simply to accelerate growth, creating reservoirs of resistant bacteria that respect no boundary between farm and clinic. Confronted with the prospect of a "post-antibiotic era"—a world in which routine surgery and minor wounds again carry real mortal risk—policymakers have begun to act. Some governments now offer pharmaceutical firms guaranteed payments for new drugs regardless of sales volume, decoupling profit from prescription. Others have curbed agricultural use and tightened the rules on prescribing. Such measures may slow the tide, but they cannot reverse evolution itself. The sobering lesson is that antibiotics were never a permanent conquest of disease, merely a temporary truce—one that humanity has been squandering with remarkable carelessness.

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この単元の問題を3問、解説つきで公開しています

準1級 · 読解 · 全5

1

What is the main idea of the passage?

  • Pharmaceutical companies have developed enough new antibiotics to defeat all superbugs.
  • Antibiotic resistance is a predictable, partly man-made crisis that policy can slow but not undo.
  • Penicillin permanently eliminated the threat of bacterial infection in the 1940s.
  • The only cause of resistance is the overuse of antibiotics in hospitals.
Phrase

the predictable product of evolution operating at breathtaking speed

準1級読解医療公衆衛生主旨把握
ひとことで

本文全体は「耐性は人為的かつ予測可能な危機で、政策で遅らせられても止められない」という論旨。

選択肢の解説Choice Analysis

Antibiotic resistance is a predictable, partly man-made crisis that policy can slow but not undo.

正解

本文は (1) 抗生物質の勝利が皮肉にも耐性を生んだ→ (2) 原因は生物学だけでなく経済・社会 (新薬枯渇・畜産での乱用)→ (3) 政策対応はあるが進化そのものは覆せない、と展開する。superbugs を an aberration ではなく the predictable product of evolution と断じ、最終段で measures may slow the tide, but they cannot reverse evolution itself と結ぶ。よって「予測可能で一部人為的な危機を政策は遅らせられても覆せない」が主旨。

  • Penicillin permanently eliminated

    = ペニシリンが感染症を永久に根絶した ━ 本文は冒頭の楽観を後で否定し、最終段で『永久の征服ではなかった』と述べるので逆。

  • developed enough new antibiotics to defeat all superbugs

    = 全ての超耐性菌を倒す新薬を十分作った ━ 本文は『新薬のパイプラインがほぼ枯渇』と明言しており正反対。

  • The only cause of resistance is the overuse of antibiotics in hospitals.

    = 唯一の原因は病院での乱用 ━ 原因は経済・社会・畜産にも及ぶと述べており『病院のみ』ではない言い過ぎ。

Collocation
パターン意味
herald a future未来の到来を告げるIt seemed to herald a future of health.
sow the seeds of ~~の種をまくTheir triumph sowed the seeds of decline.
in favour of ~~に有利にreshaped in favour of resistance
not an aberration but ~逸脱ではなく~not an aberration but a product of evolution
at breathtaking speed驚異的な速さでevolution at breathtaking speed
例文
  • The vaccine seemed to herald a future without the disease.

    そのワクチンは病のない未来の到来を告げるかに見えた。

  • Their early success sowed the seeds of later failure.

    彼らの初期の成功が後の失敗の種をまいた。

  • The outbreak was not an aberration but a predictable event.

    その発生は逸脱ではなく予測可能な出来事だった。

💡Tip · 覚えるコツ

主旨設問は最終段の結論文 (antibiotics were never a permanent conquest ... merely a temporary truce) を探すと速い。極端な肯定肢 (permanently / all / only) は本文の留保と矛盾しやすい。

2

According to the passage, why has the development of new antibiotics nearly stopped?

  • A short course of antibiotics is far less profitable for drug companies than a medicine taken indefinitely.
  • Scientists have concluded that resistance makes any new antibiotic impossible to create.
  • Governments have legally banned the research and sale of new antibiotics.
  • Patients have refused to take any newly developed antibiotic drugs.
Phrase

a drug taken for ten days is far less lucrative than one taken for a lifetime

準1級読解医療公衆衛生詳細把握
ひとことで

10日の短期投与は生涯服用の薬より遥かに儲からない→新薬開発が止まった。

選択肢の解説Choice Analysis

A short course of antibiotics is far less profitable for drug companies than a medicine taken indefinitely.

正解

第2段で『製薬会社にとって10日服用の薬は生涯服用の薬より遥かに lucrative (儲かる) でない』と述べ、その結果 the pipeline of genuinely new antibiotics has nearly run dry と結ぶ。これを言い換えた「短期投与は無期限服用の薬より遥かに利益が少ない」が正解。

  • Governments everywhere have legally banned both the research into and the sale of new antibiotics.

    = 法的に研究販売を禁止した ━ 法的禁止の記述はない。問題は利益動機の欠如であって禁止ではない。

  • impossible to create

    = 新薬を作るのは不可能 ━ 本文は『不可能』ではなく『儲からないから作られない』と述べている。

  • Patients everywhere have refused to take any of the newly developed antibiotic drugs at all.

    = 患者が拒否した ━ 患者の拒否という記述は一切ない。

Collocation
パターン意味
run dry枯渇するThe pipeline has run dry.
far less lucrative than ~~より遥かに儲からないless lucrative than a lifelong drug
move on立ち去る・次へ進むCured patients move on.
as a resultその結果As a result, research stalled.
the pipeline of ~~の開発系列the pipeline of new drugs
例文
  • The supply of new ideas had nearly run dry.

    新しい着想の供給はほぼ枯渇していた。

  • A one

    time cure is less lucrative than a lifelong treatment. — 一度きりの治療は生涯の治療より儲からない。

  • As a result, few firms invest in such research.

    その結果、そんな研究に投資する企業は少ない。

💡Tip · 覚えるコツ

detail 設問は本文の語を別語に置換した選択肢が正解になりやすい (lucrative→profitable, for a lifetime→indefinitely)。法的禁止など本文にない極端な事実は誤答。

3

What does the passage say about the use of antibiotics in agriculture?

  • Antibiotics are given to healthy livestock to speed growth, breeding resistant bacteria that spread beyond farms.
  • Farm antibiotics remain safely confined to livestock and never reach clinics.
  • Agricultural use of antibiotics has been completely eliminated by every government.
  • Antibiotics are used in agriculture only to treat seriously ill animals.
Phrase

fed to healthy livestock simply to accelerate growth, creating reservoirs of resistant bacteria

準1級読解医療公衆衛生詳細把握
ひとことで

畜産では成長促進のため健康な家畜に大量投与→耐性菌の貯蔵庫が農場と臨床を越えて広がる。

選択肢の解説Choice Analysis

Antibiotics are given to healthy livestock to speed growth, breeding resistant bacteria that spread beyond farms.

正解

第2段末で『農業では大量の抗生物質が成長促進のためだけに健康な家畜に与えられ、農場と臨床の境界を尊重しない耐性菌の reservoirs (貯蔵庫) を生む』と述べる。これを言い換えた「健康な家畜に成長促進目的で投与し、農場を越えて広がる耐性菌を育てる」が正解。

  • Antibiotics are used in agriculture only in order to treat those animals that are seriously ill.

    = 重病の動物の治療のみ ━ 本文は『健康な家畜に成長促進のため』と述べており正反対。

  • The agricultural use of antibiotics has by now been completely eliminated by every single government.

    = 全政府が完全に廃止した ━ 本文は一部政府が curbed (抑制) したと述べるだけで『全廃』ではない言い過ぎ。

  • The antibiotics used on farms remain safely confined to livestock and never once reach the clinics.

    = 臨床には決して達しない ━ 本文は『農場と臨床の境界を尊重しない』と明言しており逆。

Collocation
パターン意味
be fed to ~~に与えられるAntibiotics are fed to livestock.
accelerate growth成長を促進するdrugs used to accelerate growth
a reservoir of ~~の貯蔵庫・温床a reservoir of resistant bacteria
respect no boundary境界を顧みないbacteria that respect no boundary
vast quantities of ~膨大な量の~vast quantities of antibiotics
例文
  • Hormones are fed to livestock to accelerate growth.

    ホルモンが成長促進のため家畜に与えられる。

  • Wetlands act as a reservoir of biodiversity.

    湿地は生物多様性の貯蔵庫として働く。

  • Pollution respects no boundary between nations.

    汚染は国家間の境界を顧みない。

💡Tip · 覚えるコツ

detail 設問では『only / never / every / completely』を含む選択肢を疑う。本文は『境界を尊重しない (respect no boundary)』=越えて広がる、と反対方向の言い換えを正解に置く。

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